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For most travellers, Malaria is easily prevented with the huge range of prophylaxis available, however if you would rather not have to worry about taking medication, or if you are travelling with young children or elderly family members, then you needn’t worry. There is are some fantastic Big 5 game reserves to choose from where there is no risk at all of catching malaria. All are easily accessible from Johannesburg or Cape Town and will not detract from your safari experience. Our Africa&You experts will listen to any concerns you may have and advise on the best places to stay to experience the safari holiday of a life-time without having to worry about your health, or that of your loved ones.


See the Big 5 without having to worry about being bitten by mosquitos or having to take regular medication to prevent malaria

Cape Town

A vibrant city experience under the majestic Table Mountain


Drift away in on a chain of tropical paradise islands

Garden Route

Spectacular lines, tranquil coves, coastal villages, whales, dolphins and sunshine


Peace of mind & outstanding malaria-free game viewing


We’ve partnered with only the finest establishments to ensure the ultimate luxury safari experience in Africa


Garden Route | South Africa

A luxurious eco-paradise at the southern tip of Africa

Madikwe Safari Lodge

Madikwe | South Africa

Luxury & outstanding game viewing in a malaria-free reserve

Camp Amalinda

Southern Zimbabwe | Zimbabwe

African-inspired granite luxury in Matobo Hills


Browse some malaria-free itineraries that we have recently created for clients. Like what you see? Let us design a tailor-made itinerary for you, including the best malaria free destinations, lodges and hotels.

Contact one of our experts for a personalised quote


8 Nights / 9 Days

Cape Town one of the most child friendly cities in the world is a perfect combination of a city living in harmony with nature. With beautiful beaches, many natural and city parks its the perfect playground. Cape Town has many family friendly shopping centres, activities and restaurants. Madikwe Game Reserve is family friendly and most importantly malaria free with excellent big 5 game viewing. A South African experience perfect for every family.

View complete Itinerary


Ask one of our Africa experts to start designing your tailor-made itinerary


Help us better understand your individual travel needs and wishes


"Simply amazing!"

Angela Amos

Oh Serengeti, you were so good to us! Big 5 plus so much more! Simply AMAZING! Ready for the next adventure! Thank you Africa&You for putting it together so perfectly!

"Everything was perfect and memorable"

Pat Hanlon

We completely enjoyed every recommendation. Everything was perfect and memorable. We've travelled a lot but this one may take the cake. You are wonderful people whom we are very happy to know and to work with.

"The experience of a lifetime"

Melanie Buren

I couldn't have been happier with the experience I had with Africa&You. Belinda was so helpful, and SO patient with me regarding all my worries regarding the upcoming trip. And the trip itself was unforgettable! Not only were the adventures I had more than I could've ever dreamed, but the organization (being picked up and taken to each destination on time and without a glitch) was extremely impressive.

"The perfect honeymoon"

Kate & Steve

I can't thank you enough for putting together the perfect honeymoon for us. You really paid attention to detail and met our every wish and much more! I couldn't have dreamt of a better 2 weeks. Thank you. We'll be back!

"Amazing family holiday"

Andrew Proctor

Created a fantastic trip which felt personalized for me and my young family. Recommend Africa&You to anyone.

"Amazing value without comprimising on quality"

Jane & Nick

From a safari in the Serengeti to tropical beaches, everything was perfect. No hassles, no stress, just an amazing holiday. Africa&You gives the best recommendations and incredible value without compromising on quality. We'll be coming back to you for sure!

"honeymoon paradise"

Rachel & Anthony

We had the most magical & unforgettable 10 days in paradise. Thank you to the A&Y team for creating a honeymoon we will remember forever.

"An exceptional itinerary"

Darren Cooper

I can't give enough thanks for the trip that you organised for me at very short notice. You produced an exceptional itinerary that took in Cape Town, Safari and the winelands. We were blown away by the whole experience which was wholly due to the fantastic service you provided. We can't wait to return to South Africa with your assistance again.

"Passionate and dedicated"

Jolene du Plessis

An excellent tour operator who doesn't treat you like a number. Belinda takes the time to listen to all your concerns and interests and puts forward the best options for you. She is passionate about Africa Travel - that's what makes the difference!

"Couldn't recommend better!"

Jono Durham

Amazing operator with exceptional service right from the beginning. I felt well taken care of and the lodge choice was exceptional. Couldn't recommend better!

"Such an amazing experience"

Lucy Trafford

We had such an awesome time. Thank you so much for organizing for us!

"We will recommend your services.... "

Lyudmila Young

We are very grateful for your planing of the trip. We all found South Africa to be a beautiful country and will recommend your service to our families and friends. Thank you!

"The perfect honeymoon..."

Jamie & Kate

Thank you so much for organising an incredible honeymoon for us Rachel. You were a superstar and planned everything perfectly.

"Probably the best getaway we've ever had"

Jane McCauley

I wanted to thank you again for your great work arranging our trip. It really could not have gone more smoothly -- absolutely no issues and everyone was wonderful. Probably the best getaway we've ever had.